Conventional vs. Recombinant Antigen Based Detection of Mycobacterim avium subspecies paratuberculosis Infection in Animals

Abstract

Paratuberculosis is an enteric disease caused by Mycobacterium avium subsp. paratuberculosis (Map) in domestic and wild ruminants. Johne’s disease causes huge production losses and has high impact on animal industry. Due to the lack of simple and efficient diagnostic tests, the control programmes are hampered especially for sub clinically infected animals. Various diagnostic tools are available like faecal culture techniques, culturing, radio-isotyping, PCR based methods, serological approaches (Cell mediated assay and humoral based) and most new area are recombinant antigens-based detection which can open a novel approach for early detection of the disease.