Pharmacokinetics and Bioavailability of Ceftriaxone in Patanwadi Sheep

Abstract

Pharmacokinetics of ceftriaxone following single dose intravenous and intramuscular administration (10 mg/kg) in six Patanwadi sheep was determined. The plasma concentration-time curves were characteristic of a two and one-compartment open model following intravenous and intramuscular administration, respectively. Following intravenous administration the area under plasma drug concentration-time curve (AUC), apparent volume of distribution (Vdarea), elimination half-life (t1/2b) and total body clearance (ClB) were calculated to be 42.65 ± 1.36 µg.h/mL, 0.41 ± 0.02 L/kg, 1.21 ± 0.05 h and 3.91 ± 0.13 mL/min/kg, respectively. Peak plasma drug concentration of 15.53 ± 0.71 µg/mL was obtained at 0.5 h after intramuscular administration. The area under plasma drug concentration-time curve (AUC), apparent volume of distribution (Vdarea), elimination half-life and total body clearance (ClB) were 47.68 ± 1.31 µg.h/mL, 0.43 ± 0.02 L/kg, 2.24 ± 0.07 h and 2.22 ± 0.12 mL/min/kg, respectively. The intramuscular bioavailability of the drug was 64.0 ± 2.0%. Pharmacokinetic profile and moderate bioavailability of ceftriaxone indicated that the drug can be used intramuscularly to treat susceptible bacterial infections in sheep.