Immunopathology of Ochratoxicosis - A in New Zealand White Rabbits (Oryctolagus cuniculus)

Authors

  • M. S. Mir Indian Veterinary Research Institute, Izatnagar-243122 (U.P)
  • P. Dwivedi Indian Veterinary Research Institute, Izatnagar-243122 (U.P)

Keywords:

Immunopathology, immunosuppression, Ochratoxin-A, rabbit

Abstract

Immunopathological effects of ochratoxin-A (OT-A) were evaluated in young (8 weeks old) rabbits following experimental exposures to OT-A @ 0, 1 and 2 ppm of feed for 8 weeks. OT-A caused a significant depression in humoral and cell mediated immune responses, as reflected by decreased antibody titers to sRBC, DH response to DNCB and PHA, and mitogenic response of lymphocytes to PHA-M and Con-A; depletion of lymphoid cells in primary and secondary lymphoid organs; higher establishment of the pathogen viz. Pasteurella multocida and greater susceptibility to the ensuing disease. However, feeding of OT-A up to 15 days did not alter NK cell activity.

Author Biographies

M. S. Mir, Indian Veterinary Research Institute, Izatnagar-243122 (U.P)

Division of Pathology

P. Dwivedi, Indian Veterinary Research Institute, Izatnagar-243122 (U.P)

Division of Pathology

Abdominal hernia in a calf

Published

2010-12-31

Issue

Vol. 5 No. 1

Section

Research Articles