In Vitro Sensitivity of Aspergillus Species Isolated from Respiratory Tract of Falcons

Abstract

One hundred seventeen fungal isolates , A. Fumigates (71), A. Flavus (23), A. Niger (14), and A. Terreus (9) obtained from the air sac of falcons affected with respiratory Aspergillosis, were subjected to sensitivity test to determine in-vitro sensitivity of different Aspergillus species against widely used anti-fungal agents. All the (117) isolates were found sensitive to voriconazole and posaconazole and ninety seven percent (114) of the isolates were sensitive to itraconazole with a MIC ≤1µg/ml. Eighty percent (94) of the isolates, including 88.7% (63) of A. fumigatus, 42.8% (6) of A. niger, 100% (16) of A. flavus and 100% (9) of A. terreus were resistant to amphotericin B with a MIC >1 µg/ml. Eighty six percent (100) of the isolates, including 87.3% (62) of A. fumigatus, 74% (17) of A. flavus, 86% (12) of A. niger and 100% (9) of A. terreus were resistant to ketoconazole with a MIC >1µg/ml. All isolates were resistant to 5-flucystosine with a MIC ≥ 2µg/ml; caspofungin with a MIC ≥ 16µg/ml and fluconazole with a MIC ≥ 256µg/ml.